The product uses an unique plant extract Phylox™ which has been clinically proven to improve mobility and reduce discomfort associated with joint health problems*

PROVO, Utah-June 4, 2004- To aid the growing number of individuals who continue to suffer from joint-related health issues, Pharmanex® will launch FlexCare™ in Japan. The product contains a patented unique plant extract Phylox , which has been shown in clinical studies to improve mobility and discomfort associated with joint health problems*

Pharmanex® has obtained exclusive distribution rights to Phylox™ for the network marketing channel. In combination with Phylox™, Pharmanex® also included significant dosages of glucosamine, matching the levels found to be effective in clinical studies (1500 mg/day) and a blend of antioxidants to counteract the negative effects of free radicals.*

"We are confident that we have developed an effective product that uses ingredients that have been validated through scientific testing," said Dr. Joseph Chang, president of Pharmanex . "Exclusive for our channel, FlexCare™ contains an unique mix of ingredients that promote joint health and regular joint mobility."*

Clinical Studies Prove Effectiveness of Proprietary Ingredients

Phylox™
In-house studies have shown the blend of extracts in Phylox™ effectively inhibit COX enzyme activity without any side effects typically associated with pharmaceutical drugs. Phylox™ was effective in improving mobility and joint health.

Glucosamine
There is a substantial amount of clinical research that has shown that glucosamine supplementation can contribute to cartilage and joint health, and can reduce the stiffness and discomfort associated with various joint-related conditions, (Canapp et al. 1999;da Camara and Dowless 1998;Deal and Moskowitz 1999;Foerster et al. 1996;Gottlieb 1997;Hoffer et al. 2001;Kelly 1998;Leffler et al. 1999;McAlindon et al. 2000;McCarty ;Moon and Kang 1992;Pavelka et al. 2002;Popov, V 1989;Pujalte et al. 1980;Reginster et al. 2001;Shankland 1998;Thie et al. 2001;Vajaradul 1981;Vidal et al. 1978).

Antioxidants
Quercetin and lutein are types of flavonoids, naturally occurring antioxidants found in many types of plants, particularly fruits and vegetables. Flavonoids in general have been shown to have positive results with joint health properties in addition to their ability to scavenge free radicals. There are several studies that have shown that bioflavonoids in general, as well as those from ginkgo biloba, chocolate and citrus and other fruits specifically, have powerful antioxidant actions (Borissova et al. 1994; Kaulich et al. 2003; Loggia et al. 1993; Manthey et al. 2001; Rahman et al. 2003; Robak and Gryglewski 1996; Schewe et al. 2002; Zhang and Yu 2000).

Quercetin and lutein are two types of flavonoids that have been shown to directly reduce problems associated with joint health (Katsarou et al. 2000; Rauha et al.; Romero et al. 1989; Wang et al. 2003; Yanoshita et al. 1996; Yasukawa et al. 1991). Antioxidant vitamins have likewise been shown to have important joint health properties in addition to their anti-oxidant capabilities (Abate et al. 2000; Bandt et al. 2002; Brigelius-Flohe et al. 2002; Bulger and Maier 2003; Cerna et al. 1992; Davis et al. 1990; Fuchs and Kern 1900; Hanninen et al. 2000; Hunt 1986; Jiang et al. 2000; Langlois et al. 2001; Roberts et al. 1984).

About FlexCare
FlexCare™ provides a comprehensive blend of ingredients that promote joint health and regular joint mobility. FlexCare™ contains glucosamine, the antioxidant vitamins C and E, the flavonoids quercetin and rutin, and Phylox™, a patented plant extract, for comprehensive nutritional and joint support. Phylox™ inhibits the enzymes responsible for joint health problems. Each daily dose of FlexCare™ provides 250 mg of Phylox. Glucosamine is a nutritional building block for the structural components (glycosaminoglycans) of joints and cartilage and helps maintain normal structure and function of healthy joints. FlexCare™ supplies 1500 mg of glucosamine.*

The Company
Pharmanex®, a Nu Skin Enterprises company, is a leader in the research and development of nutritional products. The company offers multivitamin/mineral supplements, natural health products, standardized botanicals and specialized health systems. Pharmanex® products are sold direct to the consumer through the Internet and a network of independent distributors. For more information, go to www.pharmanex.com.